DES
DES Brand names, DES Analogs
DES Brand Names Mixture
- No information avaliable
DES Chemical_Formula
C18H22N2
DES RX_link
http://www.rxlist.com/cgi/generic2/desipram.htm
DES fda sheet
DES msds (material safety sheet)
DES Synthesis Reference
No information avaliable
DES Molecular Weight
266.381 g/mol
DES Melting Point
214-218 oC
DES H2O Solubility
No information avaliable
DES State
Solid
DES LogP
3.87
DES Dosage Forms
Tablet
DES Indication
For relief of symptoms in various depressive syndromes, especially endogenous depression.
DES Pharmacology
Desipramine, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. Desipramine is used to treat depression, pain of neuropathic origin, attention_deficit hyperactivity disorder, functional enuresis in children, panic and phobic disorder, and to manage some eating disorders. Desipramine inhibits the re-uptake of noradrenaline at the noradrenergic nerve endings and the re-uptake of serotonin (5-hydroxy tryptamine) at the serotoninergic nerve endings in the central nervous system. These two effects are considered to be the likely base of the antidepressant effect of Desipramine. The drug also has a strong anticholinergic effect and serves as an antagonist on a1 and H1 receptors.
DES Absorption
Desipramine hydrochloride is rapidly and almost completely absorbed from the gastrointestinal tract. 90.5% (range 73-92%) of desipramine binds to plasma proteins.
DES side effects and Toxicity
Male mice: LD50 = 290 mg/kg, female rats: LD50 = 320 mg/kg
DES Patient Information
No information avaliable
DES Organisms Affected
Humans and other mammals
