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DES Brand names, DES Analogs

DES Brand Names Mixture

  • No information avaliable

DES Chemical_Formula


DES RX_link

DES fda sheet


DES msds (material safety sheet)


DES Synthesis Reference

No information avaliable

DES Molecular Weight

266.381 g/mol

DES Melting Point

214-218 oC

DES H2O Solubility

No information avaliable

DES State




DES Dosage Forms


DES Indication

For relief of symptoms in various depressive syndromes, especially endogenous depression.

DES Pharmacology

Desipramine, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. Desipramine is used to treat depression, pain of neuropathic origin, attention_deficit hyperactivity disorder, functional enuresis in children, panic and phobic disorder, and to manage some eating disorders. Desipramine inhibits the re-uptake of noradrenaline at the noradrenergic nerve endings and the re-uptake of serotonin (5-hydroxy tryptamine) at the serotoninergic nerve endings in the central nervous system. These two effects are considered to be the likely base of the antidepressant effect of Desipramine. The drug also has a strong anticholinergic effect and serves as an antagonist on a1 and H1 receptors.

DES Absorption

Desipramine hydrochloride is rapidly and almost completely absorbed from the gastrointestinal tract. 90.5% (range 73-92%) of desipramine binds to plasma proteins.

DES side effects and Toxicity

Male mice: LD50 = 290 mg/kg, female rats: LD50 = 320 mg/kg

DES Patient Information

No information avaliable

DES Organisms Affected

Humans and other mammals