H2 Bloc en es it fr

H2 Bloc Brand names, H2 Bloc Analogs

H2 Bloc Brand Names Mixture

  • No information avaliable

H2 Bloc Chemical_Formula


H2 Bloc RX_link


H2 Bloc fda sheet

H2_Bloc FDA

H2 Bloc msds (material safety sheet)

H2_Bloc MSDS

H2 Bloc Synthesis Reference

H. Yasufumi et al.; U.S. Pat. 4,283,408 (1981)

H2 Bloc Molecular Weight

337.449 g/mol

H2 Bloc Melting Point

163-164 oC

H2 Bloc H2O Solubility

1.1 mg/mL

H2 Bloc State


H2 Bloc LogP


H2 Bloc Dosage Forms

Oral tablets; Rapid disintergrating tablets; Suspension; Injectable solution

H2 Bloc Indication

For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).

H2 Bloc Pharmacology

Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.

H2 Bloc Absorption

The bioavailability of oral doses is 40-45%.

H2 Bloc side effects and Toxicity

Intravenous, mouse: LD50 = 244.4mg/kg; Oral, mouse: LD50 = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.

H2 Bloc Patient Information

Famotidine is used to treat stomach and duodenal (upper small intestine) ulcers;
hypersecretory (increased acid secretion) conditions; heartburn and gastroesophageal
reflux disease (stomach contents bubbling into the esophagus causing pain). Notify your
physician if you are pregnant or nursing. Famotidine may be taken with or without food.
Shake the oral suspension vigorously for 5-10 seconds before taking. Unused oral
suspension should be discarded after 30 days. Notify your physician if you develop black,
tarry stools or coffee-ground vomit.

H2 Bloc Organisms Affected

Humans and other mammals