H2_Bloc
Category
H2_Bloc Brand names, H2_Bloc Analogs
H2_Bloc Brand Names Mixture
No information avaliable
H2_Bloc Chemical_Formula
C8H15N7O2S3
H2_Bloc RX_link
http://www.rxlist.com/cgi/generic/famot.htm
H2_Bloc fda sheet
H2_Bloc msds (material safety sheet)
H2_Bloc Synthesis Reference
H. Yasufumi et al.; U.S. Pat. 4,283,408 (1981)
H2_Bloc Molecular Weight
337.449 g/mol
H2_Bloc Melting Point
163-164 oC
H2_Bloc H2O Solubility
1.1 mg/mL
H2_Bloc State
Solid
H2_Bloc LogP
-0.726
H2_Bloc Dosage Forms
Oral tablets; Rapid disintergrating tablets; Suspension; Injectable solution
H2_Bloc Indication
For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).
H2_Bloc Pharmacology
Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.
H2_Bloc Absorption
The bioavailability of oral doses is 40-45%.
H2_Bloc Toxicity
Intravenous, mouse: LD50 = 244.4mg/kg; Oral, mouse: LD50 = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.
H2_Bloc Patient Information
Famotidine is used to treat stomach and duodenal (upper small intestine) ulcers;
hypersecretory (increased acid secretion) conditions; heartburn and gastroesophageal
reflux disease (stomach contents bubbling into the esophagus causing pain). Notify your
physician if you are pregnant or nursing. Famotidine may be taken with or without food.
Shake the oral suspension vigorously for 5-10 seconds before taking. Unused oral
suspension should be discarded after 30 days. Notify your physician if you develop black,
tarry stools or coffee-ground vomit.
H2_Bloc Organisms Affected
Humans and other mammals
