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Duovel Brand names, Duovel Analogs

Duovel Brand Names Mixture

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Duovel Chemical_Formula


Duovel RX_link


Duovel fda sheet

Duovel FDA

Duovel msds (material safety sheet)

Duovel MSDS

Duovel Synthesis Reference

H. Yasufumi et al.; U.S. Pat. 4,283,408 (1981)

Duovel Molecular Weight

337.449 g/mol

Duovel Melting Point

163-164 oC

Duovel H2O Solubility

1.1 mg/mL

Duovel State


Duovel LogP


Duovel Dosage Forms

Oral tablets; Rapid disintergrating tablets; Suspension; Injectable solution

Duovel Indication

For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).

Duovel Pharmacology

Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.

Duovel Absorption

The bioavailability of oral doses is 40-45%.

Duovel side effects and Toxicity

Intravenous, mouse: LD50 = 244.4mg/kg; Oral, mouse: LD50 = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.

Duovel Patient Information

Famotidine is used to treat stomach and duodenal (upper small intestine) ulcers;
hypersecretory (increased acid secretion) conditions; heartburn and gastroesophageal
reflux disease (stomach contents bubbling into the esophagus causing pain). Notify your
physician if you are pregnant or nursing. Famotidine may be taken with or without food.
Shake the oral suspension vigorously for 5-10 seconds before taking. Unused oral
suspension should be discarded after 30 days. Notify your physician if you develop black,
tarry stools or coffee-ground vomit.

Duovel Organisms Affected

Humans and other mammals