Fadin
Category
Fadin Brand names, Fadin Analogs
Fadin Brand Names Mixture
No information avaliable
Fadin Chemical_Formula
C8H15N7O2S3
Fadin RX_link
http://www.rxlist.com/cgi/generic/famot.htm
Fadin fda sheet
Fadin msds (material safety sheet)
Fadin Synthesis Reference
H. Yasufumi et al.; U.S. Pat. 4,283,408 (1981)
Fadin Molecular Weight
337.449 g/mol
Fadin Melting Point
163-164 oC
Fadin H2O Solubility
1.1 mg/mL
Fadin State
Solid
Fadin LogP
-0.726
Fadin Dosage Forms
Oral tablets; Rapid disintergrating tablets; Suspension; Injectable solution
Fadin Indication
For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).
Fadin Pharmacology
Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.
Fadin Absorption
The bioavailability of oral doses is 40-45%.
Fadin Toxicity
Intravenous, mouse: LD50 = 244.4mg/kg; Oral, mouse: LD50 = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.
Fadin Patient Information
Famotidine is used to treat stomach and duodenal (upper small intestine) ulcers;
hypersecretory (increased acid secretion) conditions; heartburn and gastroesophageal
reflux disease (stomach contents bubbling into the esophagus causing pain). Notify your
physician if you are pregnant or nursing. Famotidine may be taken with or without food.
Shake the oral suspension vigorously for 5-10 seconds before taking. Unused oral
suspension should be discarded after 30 days. Notify your physician if you develop black,
tarry stools or coffee-ground vomit.
Fadin Organisms Affected
Humans and other mammals
