Famosan
Category
Famosan Brand names, Famosan Analogs
Famosan Brand Names Mixture
No information avaliable
Famosan Chemical_Formula
C8H15N7O2S3
Famosan RX_link
http://www.rxlist.com/cgi/generic/famot.htm
Famosan fda sheet
Famosan msds (material safety sheet)
Famosan Synthesis Reference
H. Yasufumi et al.; U.S. Pat. 4,283,408 (1981)
Famosan Molecular Weight
337.449 g/mol
Famosan Melting Point
163-164 oC
Famosan H2O Solubility
1.1 mg/mL
Famosan State
Solid
Famosan LogP
-0.726
Famosan Dosage Forms
Oral tablets; Rapid disintergrating tablets; Suspension; Injectable solution
Famosan Indication
For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).
Famosan Pharmacology
Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.
Famosan Absorption
The bioavailability of oral doses is 40-45%.
Famosan Toxicity
Intravenous, mouse: LD50 = 244.4mg/kg; Oral, mouse: LD50 = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.
Famosan Patient Information
Famotidine is used to treat stomach and duodenal (upper small intestine) ulcers;
hypersecretory (increased acid secretion) conditions; heartburn and gastroesophageal
reflux disease (stomach contents bubbling into the esophagus causing pain). Notify your
physician if you are pregnant or nursing. Famotidine may be taken with or without food.
Shake the oral suspension vigorously for 5-10 seconds before taking. Unused oral
suspension should be discarded after 30 days. Notify your physician if you develop black,
tarry stools or coffee-ground vomit.
Famosan Organisms Affected
Humans and other mammals
