Fluxid
Category
Fluxid Brand names, Fluxid Analogs
Fluxid Brand Names Mixture
No information avaliable
Fluxid Chemical_Formula
C8H15N7O2S3
Fluxid RX_link
http://www.rxlist.com/cgi/generic/famot.htm
Fluxid fda sheet
Fluxid msds (material safety sheet)
Fluxid Synthesis Reference
H. Yasufumi et al.; U.S. Pat. 4,283,408 (1981)
Fluxid Molecular Weight
337.449 g/mol
Fluxid Melting Point
163-164 oC
Fluxid H2O Solubility
1.1 mg/mL
Fluxid State
Solid
Fluxid LogP
-0.726
Fluxid Dosage Forms
Oral tablets; Rapid disintergrating tablets; Suspension; Injectable solution
Fluxid Indication
For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).
Fluxid Pharmacology
Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.
Fluxid Absorption
The bioavailability of oral doses is 40-45%.
Fluxid Toxicity
Intravenous, mouse: LD50 = 244.4mg/kg; Oral, mouse: LD50 = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.
Fluxid Patient Information
Famotidine is used to treat stomach and duodenal (upper small intestine) ulcers;
hypersecretory (increased acid secretion) conditions; heartburn and gastroesophageal
reflux disease (stomach contents bubbling into the esophagus causing pain). Notify your
physician if you are pregnant or nursing. Famotidine may be taken with or without food.
Shake the oral suspension vigorously for 5-10 seconds before taking. Unused oral
suspension should be discarded after 30 days. Notify your physician if you develop black,
tarry stools or coffee-ground vomit.
Fluxid Organisms Affected
Humans and other mammals
