Dibrit 40
Category
Dibrit 40 Brand names, Dibrit 40 Analogs
Dibrit 40 Brand Names Mixture
Dibrit 40 Chemical_Formula
C8H15N7O2S3
Dibrit 40 RX_link
http://www.rxlist.com/cgi/generic/famot.htm
Dibrit 40 fda sheet
Dibrit 40 msds (material safety sheet)
Dibrit 40 Synthesis Reference
H. Yasufumi et al.; U.S. Pat. 4,283,408 (1981)
Dibrit 40 Molecular Weight
337.449 g/mol
Dibrit 40 Melting Point
163-164 oC
Dibrit 40 H2O Solubility
1.1 mg/mL
Dibrit 40 State
Solid
Dibrit 40 LogP
-0.726
Dibrit 40 Dosage Forms
Oral tablets; Rapid disintergrating tablets; Suspension; Injectable solution
Dibrit 40 Indication
For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).
Dibrit 40 Pharmacology
Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.
Dibrit 40 Absorption
The bioavailability of oral doses is 40-45%.
Dibrit 40 side effects and Toxicity
Intravenous, mouse: LD50 = 244.4mg/kg; Oral, mouse: LD50 = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.
Dibrit 40 Patient Information
Famotidine is used to treat stomach and duodenal (upper small intestine) ulcers;
hypersecretory (increased acid secretion) conditions; heartburn and gastroesophageal
reflux disease (stomach contents bubbling into the esophagus causing pain). Notify your
physician if you are pregnant or nursing. Famotidine may be taken with or without food.
Shake the oral suspension vigorously for 5-10 seconds before taking. Unused oral
suspension should be discarded after 30 days. Notify your physician if you develop black,
tarry stools or coffee-ground vomit.
Dibrit 40 Organisms Affected
Humans and other mammals
