Cronol
Category
Cronol Brand names, Cronol Analogs
Cronol Brand Names Mixture
Cronol Chemical_Formula
C8H15N7O2S3
Cronol RX_link
http://www.rxlist.com/cgi/generic/famot.htm
Cronol fda sheet
Cronol msds (material safety sheet)
Cronol Synthesis Reference
H. Yasufumi et al.; U.S. Pat. 4,283,408 (1981)
Cronol Molecular Weight
337.449 g/mol
Cronol Melting Point
163-164 oC
Cronol H2O Solubility
1.1 mg/mL
Cronol State
Solid
Cronol LogP
-0.726
Cronol Dosage Forms
Oral tablets; Rapid disintergrating tablets; Suspension; Injectable solution
Cronol Indication
For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).
Cronol Pharmacology
Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.
Cronol Absorption
The bioavailability of oral doses is 40-45%.
Cronol side effects and Toxicity
Intravenous, mouse: LD50 = 244.4mg/kg; Oral, mouse: LD50 = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.
Cronol Patient Information
Famotidine is used to treat stomach and duodenal (upper small intestine) ulcers;
hypersecretory (increased acid secretion) conditions; heartburn and gastroesophageal
reflux disease (stomach contents bubbling into the esophagus causing pain). Notify your
physician if you are pregnant or nursing. Famotidine may be taken with or without food.
Shake the oral suspension vigorously for 5-10 seconds before taking. Unused oral
suspension should be discarded after 30 days. Notify your physician if you develop black,
tarry stools or coffee-ground vomit.
Cronol Organisms Affected
Humans and other mammals
