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Fadine Brand names, Fadine Analogs

Fadine Brand Names Mixture

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Fadine Chemical_Formula


Fadine RX_link


Fadine fda sheet

Fadine FDA

Fadine msds (material safety sheet)

Fadine MSDS

Fadine Synthesis Reference

H. Yasufumi et al.; U.S. Pat. 4,283,408 (1981)

Fadine Molecular Weight

337.449 g/mol

Fadine Melting Point

163-164 oC

Fadine H2O Solubility

1.1 mg/mL

Fadine State


Fadine LogP


Fadine Dosage Forms

Oral tablets; Rapid disintergrating tablets; Suspension; Injectable solution

Fadine Indication

For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).

Fadine Pharmacology

Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.

Fadine Absorption

The bioavailability of oral doses is 40-45%.

Fadine side effects and Toxicity

Intravenous, mouse: LD50 = 244.4mg/kg; Oral, mouse: LD50 = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.

Fadine Patient Information

Famotidine is used to treat stomach and duodenal (upper small intestine) ulcers;
hypersecretory (increased acid secretion) conditions; heartburn and gastroesophageal
reflux disease (stomach contents bubbling into the esophagus causing pain). Notify your
physician if you are pregnant or nursing. Famotidine may be taken with or without food.
Shake the oral suspension vigorously for 5-10 seconds before taking. Unused oral
suspension should be discarded after 30 days. Notify your physician if you develop black,
tarry stools or coffee-ground vomit.

Fadine Organisms Affected

Humans and other mammals