Hacip
Category
Hacip Brand names, Hacip Analogs
Hacip Brand Names Mixture
No information avaliable
Hacip Chemical_Formula
C8H15N7O2S3
Hacip RX_link
http://www.rxlist.com/cgi/generic/famot.htm
Hacip fda sheet
Hacip msds (material safety sheet)
Hacip Synthesis Reference
H. Yasufumi et al.; U.S. Pat. 4,283,408 (1981)
Hacip Molecular Weight
337.449 g/mol
Hacip Melting Point
163-164 oC
Hacip H2O Solubility
1.1 mg/mL
Hacip State
Solid
Hacip LogP
-0.726
Hacip Dosage Forms
Oral tablets; Rapid disintergrating tablets; Suspension; Injectable solution
Hacip Indication
For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).
Hacip Pharmacology
Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.
Hacip Absorption
The bioavailability of oral doses is 40-45%.
Hacip Toxicity
Intravenous, mouse: LD50 = 244.4mg/kg; Oral, mouse: LD50 = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.
Hacip Patient Information
Famotidine is used to treat stomach and duodenal (upper small intestine) ulcers;
hypersecretory (increased acid secretion) conditions; heartburn and gastroesophageal
reflux disease (stomach contents bubbling into the esophagus causing pain). Notify your
physician if you are pregnant or nursing. Famotidine may be taken with or without food.
Shake the oral suspension vigorously for 5-10 seconds before taking. Unused oral
suspension should be discarded after 30 days. Notify your physician if you develop black,
tarry stools or coffee-ground vomit.
Hacip Organisms Affected
Humans and other mammals
