Procarbazine

• Antineoplastic Agents
• ATC:L01XB01

• IBZ
• Ibenzmethyzin
• Ibenzmethyzine
• Ibenzmethyzine hydrochloride
• MBH
• MIH
• Matulane
• Mih Hydrochloride
• Nathulane
• Natulan
• Natulan hydrochloride
• Natulanar
• Natunalar
• PCB
• PCX
• PCB hydrochloride
• Procarbazin
• Procarbazin [German]
• Procarbazina [Inn-Spanish]
• Procarbazine hydrochloride
• Procarbazinum [Inn-Latin]

• No information avaliable

C₁₂H₁₉N₃O

http://www.rxlist.com/cgi/generic3/procarb.htm

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=44

Procarbazine MSDS

No information avaliable

221.299 g/mol

223 ^oC

1420 mg/L

Solid

1.234

Capsule

For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.

Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Procarbazine is cell-phase specific for the S phase of cell division.

Procarbazine is rapidly and completely absorbed.

LD₅₀=785 mg/kg (orally in rats)

Humans and other mammals