PCB hydrochloride
PCB hydrochloride Brand names, PCB hydrochloride Analogs
PCB hydrochloride Brand Names Mixture
- No information avaliable
PCB hydrochloride Chemical_Formula
C12H19N3O
PCB hydrochloride RX_link
http://www.rxlist.com/cgi/generic3/procarb.htm
PCB hydrochloride fda sheet
PCB hydrochloride msds (material safety sheet)
PCB hydrochloride Synthesis Reference
No information avaliable
PCB hydrochloride Molecular Weight
221.299 g/mol
PCB hydrochloride Melting Point
223 oC
PCB hydrochloride H2O Solubility
1420 mg/L
PCB hydrochloride State
Solid
PCB hydrochloride LogP
1.234
PCB hydrochloride Dosage Forms
Capsule
PCB hydrochloride Indication
For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.
PCB hydrochloride Pharmacology
Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Procarbazine is cell-phase specific for the S phase of cell division.
PCB hydrochloride Absorption
Procarbazine is rapidly and completely absorbed.
PCB hydrochloride side effects and Toxicity
LD50=785 mg/kg (orally in rats)
PCB hydrochloride Patient Information
PCB hydrochloride Organisms Affected
Humans and other mammals
