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PCB hydrochloride Brand names, PCB hydrochloride Analogs

PCB hydrochloride Brand Names Mixture

  • No information avaliable

PCB hydrochloride Chemical_Formula

C12H19N3O

PCB hydrochloride RX_link

http://www.rxlist.com/cgi/generic3/procarb.htm

PCB hydrochloride fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=44

PCB hydrochloride msds (material safety sheet)

PCB_hydrochloride MSDS

PCB hydrochloride Synthesis Reference

No information avaliable

PCB hydrochloride Molecular Weight

221.299 g/mol

PCB hydrochloride Melting Point

223 oC

PCB hydrochloride H2O Solubility

1420 mg/L

PCB hydrochloride State

Solid

PCB hydrochloride LogP

1.234

PCB hydrochloride Dosage Forms

Capsule

PCB hydrochloride Indication

For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.

PCB hydrochloride Pharmacology

Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Procarbazine is cell-phase specific for the S phase of cell division.

PCB hydrochloride Absorption

Procarbazine is rapidly and completely absorbed.

PCB hydrochloride side effects and Toxicity

LD50=785 mg/kg (orally in rats)

PCB hydrochloride Patient Information

PCB hydrochloride Organisms Affected

Humans and other mammals