Procarbazin [German]

Procarbazin [German] Brand names, Procarbazin [German] Analogs

Procarbazin [German] Brand Names Mixture

No information avaliable

Procarbazin [German] Chemical_Formula

C₁₂H₁₉N₃O

Procarbazin [German] RX_link

http://www.rxlist.com/cgi/generic3/procarb.htm

Procarbazin [German] fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=44

Procarbazin [German] msds (material safety sheet)

Procarbazin_[German] MSDS

Procarbazin [German] Synthesis Reference

No information avaliable

Procarbazin [German] Molecular Weight

221.299 g/mol

Procarbazin [German] Melting Point

223 ^oC

Procarbazin [German] H₂O Solubility

1420 mg/L

Procarbazin [German] State

Solid

Procarbazin [German] LogP

1.234

Procarbazin [German] Dosage Forms

Capsule

Procarbazin [German] Indication

For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.

Procarbazin [German] Pharmacology

Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Procarbazine is cell-phase specific for the S phase of cell division.

Procarbazin [German] Absorption

Procarbazine is rapidly and completely absorbed.

Procarbazin [German] side effects and Toxicity

LD₅₀=785 mg/kg (orally in rats)

Procarbazin [German] Patient Information

Procarbazin [German] Organisms Affected

Humans and other mammals