Procarbazin
Procarbazin Brand names, Procarbazin Analogs
Procarbazin Brand Names Mixture
- No information avaliable
Procarbazin Chemical_Formula
C12H19N3O
Procarbazin RX_link
http://www.rxlist.com/cgi/generic3/procarb.htm
Procarbazin fda sheet
Procarbazin msds (material safety sheet)
Procarbazin Synthesis Reference
No information avaliable
Procarbazin Molecular Weight
221.299 g/mol
Procarbazin Melting Point
223 oC
Procarbazin H2O Solubility
1420 mg/L
Procarbazin State
Solid
Procarbazin LogP
1.234
Procarbazin Dosage Forms
Capsule
Procarbazin Indication
For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.
Procarbazin Pharmacology
Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Procarbazine is cell-phase specific for the S phase of cell division.
Procarbazin Absorption
Procarbazine is rapidly and completely absorbed.
Procarbazin side effects and Toxicity
LD50=785 mg/kg (orally in rats)
Procarbazin Patient Information
Procarbazin Organisms Affected
Humans and other mammals
