MIH
MIH Brand names, MIH Analogs
MIH Brand Names Mixture
- No information avaliable
MIH Chemical_Formula
C12H19N3O
MIH RX_link
http://www.rxlist.com/cgi/generic3/procarb.htm
MIH fda sheet
MIH msds (material safety sheet)
MIH Synthesis Reference
No information avaliable
MIH Molecular Weight
221.299 g/mol
MIH Melting Point
223 oC
MIH H2O Solubility
1420 mg/L
MIH State
Solid
MIH LogP
1.234
MIH Dosage Forms
Capsule
MIH Indication
For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.
MIH Pharmacology
Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Procarbazine is cell-phase specific for the S phase of cell division.
MIH Absorption
Procarbazine is rapidly and completely absorbed.
MIH side effects and Toxicity
LD50=785 mg/kg (orally in rats)
MIH Patient Information
MIH Organisms Affected
Humans and other mammals
