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Natulan Brand names, Natulan Analogs

Natulan Brand Names Mixture

  • No information avaliable

Natulan Chemical_Formula

C12H19N3O

Natulan RX_link

http://www.rxlist.com/cgi/generic3/procarb.htm

Natulan fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=44

Natulan msds (material safety sheet)

Natulan MSDS

Natulan Synthesis Reference

No information avaliable

Natulan Molecular Weight

221.299 g/mol

Natulan Melting Point

223 oC

Natulan H2O Solubility

1420 mg/L

Natulan State

Solid

Natulan LogP

1.234

Natulan Dosage Forms

Capsule

Natulan Indication

For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.

Natulan Pharmacology

Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Procarbazine is cell-phase specific for the S phase of cell division.

Natulan Absorption

Procarbazine is rapidly and completely absorbed.

Natulan side effects and Toxicity

LD50=785 mg/kg (orally in rats)

Natulan Patient Information

Natulan Organisms Affected

Humans and other mammals