Natulan
Natulan Brand names, Natulan Analogs
Natulan Brand Names Mixture
- No information avaliable
Natulan Chemical_Formula
C12H19N3O
Natulan RX_link
http://www.rxlist.com/cgi/generic3/procarb.htm
Natulan fda sheet
Natulan msds (material safety sheet)
Natulan Synthesis Reference
No information avaliable
Natulan Molecular Weight
221.299 g/mol
Natulan Melting Point
223 oC
Natulan H2O Solubility
1420 mg/L
Natulan State
Solid
Natulan LogP
1.234
Natulan Dosage Forms
Capsule
Natulan Indication
For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.
Natulan Pharmacology
Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Procarbazine is cell-phase specific for the S phase of cell division.
Natulan Absorption
Procarbazine is rapidly and completely absorbed.
Natulan side effects and Toxicity
LD50=785 mg/kg (orally in rats)
Natulan Patient Information
Natulan Organisms Affected
Humans and other mammals
