Nathulane
Nathulane Brand names, Nathulane Analogs
Nathulane Brand Names Mixture
- No information avaliable
Nathulane Chemical_Formula
C12H19N3O
Nathulane RX_link
http://www.rxlist.com/cgi/generic3/procarb.htm
Nathulane fda sheet
Nathulane msds (material safety sheet)
Nathulane Synthesis Reference
No information avaliable
Nathulane Molecular Weight
221.299 g/mol
Nathulane Melting Point
223 oC
Nathulane H2O Solubility
1420 mg/L
Nathulane State
Solid
Nathulane LogP
1.234
Nathulane Dosage Forms
Capsule
Nathulane Indication
For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.
Nathulane Pharmacology
Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Procarbazine is cell-phase specific for the S phase of cell division.
Nathulane Absorption
Procarbazine is rapidly and completely absorbed.
Nathulane side effects and Toxicity
LD50=785 mg/kg (orally in rats)
Nathulane Patient Information
Nathulane Organisms Affected
Humans and other mammals
