PCX
PCX Brand names, PCX Analogs
PCX Brand Names Mixture
- No information avaliable
PCX Chemical_Formula
C12H19N3O
PCX RX_link
http://www.rxlist.com/cgi/generic3/procarb.htm
PCX fda sheet
PCX msds (material safety sheet)
PCX Synthesis Reference
No information avaliable
PCX Molecular Weight
221.299 g/mol
PCX Melting Point
223 oC
PCX H2O Solubility
1420 mg/L
PCX State
Solid
PCX LogP
1.234
PCX Dosage Forms
Capsule
PCX Indication
For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.
PCX Pharmacology
Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Procarbazine is cell-phase specific for the S phase of cell division.
PCX Absorption
Procarbazine is rapidly and completely absorbed.
PCX side effects and Toxicity
LD50=785 mg/kg (orally in rats)
PCX Patient Information
PCX Organisms Affected
Humans and other mammals
