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MBH Brand names, MBH Analogs

MBH Brand Names Mixture

  • No information avaliable

MBH Chemical_Formula

C12H19N3O

MBH RX_link

http://www.rxlist.com/cgi/generic3/procarb.htm

MBH fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=44

MBH msds (material safety sheet)

MBH MSDS

MBH Synthesis Reference

No information avaliable

MBH Molecular Weight

221.299 g/mol

MBH Melting Point

223 oC

MBH H2O Solubility

1420 mg/L

MBH State

Solid

MBH LogP

1.234

MBH Dosage Forms

Capsule

MBH Indication

For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.

MBH Pharmacology

Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Procarbazine is cell-phase specific for the S phase of cell division.

MBH Absorption

Procarbazine is rapidly and completely absorbed.

MBH side effects and Toxicity

LD50=785 mg/kg (orally in rats)

MBH Patient Information

MBH Organisms Affected

Humans and other mammals