MBH
MBH Brand names, MBH Analogs
MBH Brand Names Mixture
- No information avaliable
MBH Chemical_Formula
C12H19N3O
MBH RX_link
http://www.rxlist.com/cgi/generic3/procarb.htm
MBH fda sheet
MBH msds (material safety sheet)
MBH Synthesis Reference
No information avaliable
MBH Molecular Weight
221.299 g/mol
MBH Melting Point
223 oC
MBH H2O Solubility
1420 mg/L
MBH State
Solid
MBH LogP
1.234
MBH Dosage Forms
Capsule
MBH Indication
For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.
MBH Pharmacology
Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Procarbazine is cell-phase specific for the S phase of cell division.
MBH Absorption
Procarbazine is rapidly and completely absorbed.
MBH side effects and Toxicity
LD50=785 mg/kg (orally in rats)
MBH Patient Information
MBH Organisms Affected
Humans and other mammals
