IBZ
IBZ Brand names, IBZ Analogs
IBZ Brand Names Mixture
- No information avaliable
IBZ Chemical_Formula
C12H19N3O
IBZ RX_link
http://www.rxlist.com/cgi/generic3/procarb.htm
IBZ fda sheet
IBZ msds (material safety sheet)
IBZ Synthesis Reference
No information avaliable
IBZ Molecular Weight
221.299 g/mol
IBZ Melting Point
223 oC
IBZ H2O Solubility
1420 mg/L
IBZ State
Solid
IBZ LogP
1.234
IBZ Dosage Forms
Capsule
IBZ Indication
For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.
IBZ Pharmacology
Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Procarbazine is cell-phase specific for the S phase of cell division.
IBZ Absorption
Procarbazine is rapidly and completely absorbed.
IBZ side effects and Toxicity
LD50=785 mg/kg (orally in rats)
IBZ Patient Information
IBZ Organisms Affected
Humans and other mammals
