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IBZ Brand names, IBZ Analogs

IBZ Brand Names Mixture

  • No information avaliable

IBZ Chemical_Formula

C12H19N3O

IBZ RX_link

http://www.rxlist.com/cgi/generic3/procarb.htm

IBZ fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=44

IBZ msds (material safety sheet)

IBZ MSDS

IBZ Synthesis Reference

No information avaliable

IBZ Molecular Weight

221.299 g/mol

IBZ Melting Point

223 oC

IBZ H2O Solubility

1420 mg/L

IBZ State

Solid

IBZ LogP

1.234

IBZ Dosage Forms

Capsule

IBZ Indication

For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.

IBZ Pharmacology

Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Procarbazine is cell-phase specific for the S phase of cell division.

IBZ Absorption

Procarbazine is rapidly and completely absorbed.

IBZ side effects and Toxicity

LD50=785 mg/kg (orally in rats)

IBZ Patient Information

IBZ Organisms Affected

Humans and other mammals