Natulanar
Natulanar Brand names, Natulanar Analogs
Natulanar Brand Names Mixture
- No information avaliable
Natulanar Chemical_Formula
C12H19N3O
Natulanar RX_link
http://www.rxlist.com/cgi/generic3/procarb.htm
Natulanar fda sheet
Natulanar msds (material safety sheet)
Natulanar Synthesis Reference
No information avaliable
Natulanar Molecular Weight
221.299 g/mol
Natulanar Melting Point
223 oC
Natulanar H2O Solubility
1420 mg/L
Natulanar State
Solid
Natulanar LogP
1.234
Natulanar Dosage Forms
Capsule
Natulanar Indication
For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.
Natulanar Pharmacology
Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Procarbazine is cell-phase specific for the S phase of cell division.
Natulanar Absorption
Procarbazine is rapidly and completely absorbed.
Natulanar side effects and Toxicity
LD50=785 mg/kg (orally in rats)
Natulanar Patient Information
Natulanar Organisms Affected
Humans and other mammals
