Matulane
Matulane Brand names, Matulane Analogs
Matulane Brand Names Mixture
- No information avaliable
Matulane Chemical_Formula
C12H19N3O
Matulane RX_link
http://www.rxlist.com/cgi/generic3/procarb.htm
Matulane fda sheet
Matulane msds (material safety sheet)
Matulane Synthesis Reference
No information avaliable
Matulane Molecular Weight
221.299 g/mol
Matulane Melting Point
223 oC
Matulane H2O Solubility
1420 mg/L
Matulane State
Solid
Matulane LogP
1.234
Matulane Dosage Forms
Capsule
Matulane Indication
For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.
Matulane Pharmacology
Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Procarbazine is cell-phase specific for the S phase of cell division.
Matulane Absorption
Procarbazine is rapidly and completely absorbed.
Matulane side effects and Toxicity
LD50=785 mg/kg (orally in rats)
Matulane Patient Information
Matulane Organisms Affected
Humans and other mammals
