Natulan hydrochloride
Natulan hydrochloride Brand names, Natulan hydrochloride Analogs
Natulan hydrochloride Brand Names Mixture
- No information avaliable
Natulan hydrochloride Chemical_Formula
C12H19N3O
Natulan hydrochloride RX_link
http://www.rxlist.com/cgi/generic3/procarb.htm
Natulan hydrochloride fda sheet
Natulan hydrochloride msds (material safety sheet)
Natulan hydrochloride Synthesis Reference
No information avaliable
Natulan hydrochloride Molecular Weight
221.299 g/mol
Natulan hydrochloride Melting Point
223 oC
Natulan hydrochloride H2O Solubility
1420 mg/L
Natulan hydrochloride State
Solid
Natulan hydrochloride LogP
1.234
Natulan hydrochloride Dosage Forms
Capsule
Natulan hydrochloride Indication
For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.
Natulan hydrochloride Pharmacology
Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Procarbazine is cell-phase specific for the S phase of cell division.
Natulan hydrochloride Absorption
Procarbazine is rapidly and completely absorbed.
Natulan hydrochloride side effects and Toxicity
LD50=785 mg/kg (orally in rats)
Natulan hydrochloride Patient Information
Natulan hydrochloride Organisms Affected
Humans and other mammals
