Natunalar
Natunalar Brand names, Natunalar Analogs
Natunalar Brand Names Mixture
- No information avaliable
Natunalar Chemical_Formula
C12H19N3O
Natunalar RX_link
http://www.rxlist.com/cgi/generic3/procarb.htm
Natunalar fda sheet
Natunalar msds (material safety sheet)
Natunalar Synthesis Reference
No information avaliable
Natunalar Molecular Weight
221.299 g/mol
Natunalar Melting Point
223 oC
Natunalar H2O Solubility
1420 mg/L
Natunalar State
Solid
Natunalar LogP
1.234
Natunalar Dosage Forms
Capsule
Natunalar Indication
For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.
Natunalar Pharmacology
Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Procarbazine is cell-phase specific for the S phase of cell division.
Natunalar Absorption
Procarbazine is rapidly and completely absorbed.
Natunalar side effects and Toxicity
LD50=785 mg/kg (orally in rats)
Natunalar Patient Information
Natunalar Organisms Affected
Humans and other mammals
