PCB
PCB Brand names, PCB Analogs
PCB Brand Names Mixture
- No information avaliable
PCB Chemical_Formula
C12H19N3O
PCB RX_link
http://www.rxlist.com/cgi/generic3/procarb.htm
PCB fda sheet
PCB msds (material safety sheet)
PCB Synthesis Reference
No information avaliable
PCB Molecular Weight
221.299 g/mol
PCB Melting Point
223 oC
PCB H2O Solubility
1420 mg/L
PCB State
Solid
PCB LogP
1.234
PCB Dosage Forms
Capsule
PCB Indication
For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.
PCB Pharmacology
Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Procarbazine is cell-phase specific for the S phase of cell division.
PCB Absorption
Procarbazine is rapidly and completely absorbed.
PCB side effects and Toxicity
LD50=785 mg/kg (orally in rats)
PCB Patient Information
PCB Organisms Affected
Humans and other mammals
