HOFFMANN-LA ROCHE INC -- PROCARBAZINE HYDROCHLORIDE -- 6505-00-175-6061
===================== Product Identification =====================
Product ID:PROCARBAZINE HYDROCHLORIDE
MSDS Date:07/14/1989
FSC:6505
NIIN:00-175-6061
MSDS Number: BNBQR
=== Responsible Party ===
Company Name:HOFFMANN-LA ROCHE INC
Address:340 KINGSLAND ST
City:NUTLEY
State:NJ
ZIP:07110-1141
Country:US
Info Phone Num:201-235-3729 OR 201-235-2377
Emergency Phone Num:201-235-3729
CAGE:1V283
=== Contractor Identification ===
Company Name:HOFFMAN-LA ROCHE INC
Address:340 KINGSLAND ST
City:NUTLEY
State:NJ
ZIP:07110-1141
Country:US
Phone:201-235-2323
CAGE:04493
Company Name:HOFFMANN-LA ROCHE INC.
Address:200 ROCHE DRIVE
City:BELVIDERE
State:NJ
ZIP:07823-1112
Phone:(800) 526-0625
CAGE:1V283
============= Composition/Information on Ingredients =============
Ingred Name:P-TOLUAMIDE, N-ISOPROPYL-A-(2-METHYLHYDRAZINO)-,
MONOHYDROCHLORIDE; (BENZAMIDE) (PROCARBAZINE HYDROCHLORIDE
CHLORIDE)
CAS:366-70-1
RTECS #:XS4725000
Fraction by Wt: 100%
Ingred Name:SUPP DATA:WOMEN SHOULD EXERCISE CAUTION REGARDING POTNTL
EXPOS. ALSO ADVISABLE FOR NURSING MOTHERS TO EXERCISE CAUTION.
RTECS #:9999999ZZ
Ingred Name:SPILL PROC:COVER & MOVE CNTNR TO SAFE HOLDING AREA.CLEAN
SPILL AREA THORO. DECONTAM/DISPOSE OF ALL PROTECTIVE EQUIPMENT.
RTECS #:9999999ZZ
Ingred Name:WASTE DISP METH:REGULATORY AUTHOR BEFORE DETERMINING FINAL
METHOD OF DISP. DISP OF I/A/W FED, STATE & LOCAL REGS .
RTECS #:9999999ZZ
Ingred Name:OTHER PREC:CLOSED CNTNRS UNDER NITROGEN/IN AMBER BOTTLES.
AVOID ALL PERS CNTCT. DO NOT GET IN EYES, ON SKIN OR (ING 6)
RTECS #:9999999ZZ
Ingred Name:ING 5:CLTHG. DO NOT BREATHE DUST. AVOID CREATING DUST WHEN
HNDLG. USE ONLY W/ADEQ VENT. KEEP CNTNR TIGHTLY CLOSED(ING 7)
RTECS #:9999999ZZ
Ingred Name:ING 6:WHEN NOT IN USE. WHEN HNDLG, WEAR PROPER RESP & OTHER
PERS PROTECTIVE EQUIPMENT. FULL BODY SUIT RECOMMENDED.
RTECS #:9999999ZZ
Ingred Name:PROT GLOVES:NOT USE POLYVINYL CHLORIDE.INSPECT FREQUENTLY &
DISCARD WHEN THEY SHOW CUTS, TEARS, PINHOLES/SIGNS OF WEAR).
RTECS #:9999999ZZ
Ingred Name:OTHER PROT EQUIP:FULLY FASTENED DISP LAB COAT/DISP
JUMPSUIT. LAB WORK SURFS SHOULD BE COVERED W/STAINLESS STEEL,(ING
10)
RTECS #:9999999ZZ
Ingred Name:ING 9:PLASTIC TRAYS, DRY ABSORB PLASTIC BACKED PAPER/OTHER
IMPERVIOUS MATL. DECONTAM WORK SURFS & DISPOSE OF (ING 11)
RTECS #:9999999ZZ
Ingred Name:ING 10:PROTECTIVE CLOTHING OR SURFACE COVERING PROPERLY.
EMERGENCY EYEWASH, DELUGE SHOWER .
RTECS #:9999999ZZ
Ingred Name:PH: 3-4 (5% IN H*2O)
RTECS #:9999999ZZ
===================== Hazards Identification =====================
LD50 LC50 Mixture:LD50:(ORAL,RAT)785 MG/KG.
Routes of Entry: Inhalation:YES Skin:NO Ingestion:YES
Reports of Carcinogenicity:NTP:YES IARC:YES OSHA:NO
Health Hazards Acute and Chronic:ACUTE/CHRONIC:BASED ON SYMPS ASSOC
W/THERAPEUTIC USE OF MATL, MOST COMMON EFTS ARE:BLOOD CHANGES,
I.E.,DECREASE IN NUMBER OF WHITE CELLS & PLATELETS; GI EFTS,
E.G.,NAUSEA & VOMIT. OTHER REPORTED EFTS INCLUDE:CENTRAL &
PERIPHERAL NERVOUS SYS EFTS, E.G.,NUMBNESS & TINGLING SENSATIONS,
DIZZ; PSYCHO-MOTOR (EFTS OF OVEREXP)
Explanation of Carcinogenicity:PROCARBAZINE HYDROCHLORIDE: GROUP 2
(NTP), GROUP 2A (IARC).
Effects of Overexposure:HLTH HAZ:EFTS, E.G.,WEAKNESS & FATIGUE, DROWS,
HDCH; SKIN RXN, E.G.,DERM & ITCHING; MUSC EFTS, E.G.,JOINT PAIN;
RESP EFTS, E.G.,FLUID BUILD-UP IN PERITONEAL & PLEURAL CAVITY,
EDEMA, DFCLTY IN BRTHG, C OUGH; TEMP ABNORM, E.G.,CHILLS, FEVER;
BLEEDING TENDENCY, E.G.,INTRADERMAL HEMMORHAGE, NOSEBLEEDS. MAY
CAUSE (SUPP DATA)
Medical Cond Aggravated by Exposure:PROCARBAZINE HYDROCHLORIDE ALLERGY
HISTORY, IMPAIRED LIVER/KIDNEY FUNCTION; BLOOD DISTURB; BASED ON
THERAPEUTIC USE OF MATL, ADVERSE RXN MAY OCCUR W/ALCOHOLIC
BEVERAGES, E.G.,INTENSE WARMTH(SUPP DATA)
======================= First Aid Measures =======================
First Aid:EYE:FLUSH W/PLENTY OF WATER. IF IRRIT, CALL MD. SKIN:FLUSH
W/PLENTY OF WATER & WASH CNTCT AREA W/SOAP & WATER. IF IRRIT, CALL
MD. REMOVE CONTAMD CLTHG & SHOES & WASH BEFORE REUSE. INHAL:REMOVE
TO FRES H AIR. IF DISCOMFORT OCCURS/PERSISTS, CALL MD. INGEST:CALL
MD IMMEDIATELY .
===================== Fire Fighting Measures =====================
Extinguishing Media:AS APPROPRIATE FOR FIRE IN SURROUNDING MATERIALS.
Fire Fighting Procedures:WEAR NIOSH/MSHA APPROVED SCBA AND FULL
PROTECTIVE EQUIPMENT . USE WATER TO KEEP FIRE-EXPOSED CONTAINERS
COOL.
Unusual Fire/Explosion Hazard:UNKNOWN.
================== Accidental Release Measures ==================
Spill Release Procedures:EVACUATE AREA & DO NOT RETURN UNLESS PROT BY
NIOSH/MSHA APPRVD SCBA & PERS PROT CLTHG. SHUT OFF SOURCE OF
LEAK/SPILL IF SAFE TO DO SO. AVOID SKIN CNTCT/BRTHG DUSTS.
SCOOP/SHOVEL SPILLED MATL INTO SUIT ABLE LABELED OPEN-HEAD DRUM.
SECURE DRUM (ING 3)
Neutralizing Agent:NONE SPECIFIED BY MANUFACTURER.
====================== Handling and Storage ======================
Handling and Storage Precautions:UNDERGOES OXIDATION BY ATMOSPHERIC O*2
IN PRESENCE OF MOISTURE/IN AQ SOLN (AUTOXIDATION MAY BE CATALYZED
BY METAL IONS, E.G.,MANGANESE & COPPER).
Other Precautions:DEGRADES RAPIDLY IN ALCOHOLIC MEDIA. BEST STABILITY
IS IN AQUEOUS ACID. VERY SENSITIVE TO ULTRAVIOLET LIGHT. AVOID
CNTCT W/AIR & LIGHT. ALL OPERATIONS MUST BE CARRIED OUT UNDER
NITROGEN. STORE AT ROOM TEMP IN DRY PLACE IN TIGHTLY (ING 5)
============= Exposure Controls/Personal Protection =============
Respiratory Protection:USE NIOSH/MSHA APPROVED SUPPLIED-AIR
POSITIVE-PRESSURE FULL FACEPIECE RESPIRATOR OR SUPPLIED-AIR HOOD.
Ventilation:LOCAL EXHAUST:SPECIFIC VENTILATION REQUIRED.
MECHANICAL:REQUIRED. OTHER:LABORATORY-TYPE HOOD.
Protective Gloves:DISPOSABLE SURGICAL LATEX (DO (ING 8)
Eye Protection:CHEM WORK GOG & FULL LENGTH FSHLD.
Other Protective Equipment:PROD OPS:WEAR FULL BODY SUIT INCLDG HEAD &
FOOT COVERING W/SLEEVES TUCKED UNDER GLOVES & TAPED. FOR LAB
OPS:WEAR (ING 9)
Work Hygienic Practices:DECONTAM WORK SURFS & DISPOSE OF PROT
CLTHG/SURF COVERING PROPERLY. WASH THOROUGHLY OR SHOWER AFTER
HANDLING.
Supplemental Safety and Health
SOL IN H*2O:(200 MG/ML) BUT DECOMPOSES. EFTS OF OVEREXP:CANCER &
TERATOGENIC EFTS. MAY AFFECT MALE FERTILITY. MED CDNTNS: &
REDDENING OF FACE, AS WELL AS W/CERTAIN FOODS & CERTAIN OTHER
DRUGS. NOTE:SI NCE MATL MAY AFFECT MALE REPRO CAPABILITY &
DEVELOPING FETUS, MALES/FEMALES PLANNING TO HAVE A CHILD & PREGNANT
(ING 2)
================== Physical/Chemical Properties ==================
Melt/Freeze Pt:M.P/F.P Text:433F,223C
pH:ING 12
Solubility in Water:VERY SOL (SUPP DATA)
Appearance and Odor:WHITE TO PALE YELLOW CRYSTALLINE POWDER; SLIGHT,
CHARACTERISTIC ODOR.
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
Hazardous Decomposition Products:TOXIC FUMES OF OXIDES OF NITROGEN AND
HYDROGEN CHLORIDE.
==================== Disposal Considerations ====================
Waste Disposal Methods:DISPOSE OF AS HAZ WASTE. TRANSPORT TO FED &
STATE APPRVD FACILITY FOR TREATMENT, STOR/DISP OF HAZ WASTES. BURN
IN CHEM INCIN EQUIPPED W/AFTERBURNER & SCRUBBER. HAZ WASTE MANIFEST
MUST BE USED. STATE H AZ WASTE REGS MAY VARY; CHECK W/LOCAL (ING 4)
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.