Nitrogen mustard
Nitrogen mustard Brand names, Nitrogen mustard Analogs
Nitrogen mustard Brand Names Mixture
- No information avaliable
Nitrogen mustard Chemical_Formula
C14H19Cl2NO2
Nitrogen mustard RX_link
http://www.rxlist.com/cgi/generic2/leukeran.htm
Nitrogen mustard fda sheet
Nitrogen mustard msds (material safety sheet)
Nitrogen mustard Synthesis Reference
No information avaliable
Nitrogen mustard Molecular Weight
304.212 g/mol
Nitrogen mustard Melting Point
65 oC
Nitrogen mustard H2O Solubility
1.24E+004 mg/L
Nitrogen mustard State
Solid
Nitrogen mustard LogP
3.25
Nitrogen mustard Dosage Forms
Tablet
Nitrogen mustard Indication
For treatment of chronic lymphatic (lymphocytic) leukemia, malignant lymphomas including lymphosarcoma, giant follicular lymphoma, and Hodgkin's disease
Nitrogen mustard Pharmacology
Chlorambucil is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.
Nitrogen mustard Absorption
No information avaliable
Nitrogen mustard side effects and Toxicity
No information avaliable
Nitrogen mustard Patient Information
No information avaliable
Nitrogen mustard Organisms Affected
Humans and other mammals
