Linfolizin
Linfolizin Brand names, Linfolizin Analogs
Linfolizin Brand Names Mixture
- No information avaliable
Linfolizin Chemical_Formula
C14H19Cl2NO2
Linfolizin RX_link
http://www.rxlist.com/cgi/generic2/leukeran.htm
Linfolizin fda sheet
Linfolizin msds (material safety sheet)
Linfolizin Synthesis Reference
No information avaliable
Linfolizin Molecular Weight
304.212 g/mol
Linfolizin Melting Point
65 oC
Linfolizin H2O Solubility
1.24E+004 mg/L
Linfolizin State
Solid
Linfolizin LogP
3.25
Linfolizin Dosage Forms
Tablet
Linfolizin Indication
For treatment of chronic lymphatic (lymphocytic) leukemia, malignant lymphomas including lymphosarcoma, giant follicular lymphoma, and Hodgkin's disease
Linfolizin Pharmacology
Chlorambucil is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.
Linfolizin Absorption
No information avaliable
Linfolizin side effects and Toxicity
No information avaliable
Linfolizin Patient Information
No information avaliable
Linfolizin Organisms Affected
Humans and other mammals
