PharmacyCodes



Chlorobutine en es it fr

Chlorobutine Brand names, Chlorobutine Analogs

Chlorobutine Brand Names Mixture

  • No information avaliable

Chlorobutine Chemical_Formula

C14H19Cl2NO2

Chlorobutine RX_link

http://www.rxlist.com/cgi/generic2/leukeran.htm

Chlorobutine fda sheet

Chlorobutine FDA

Chlorobutine msds (material safety sheet)

Chlorobutine MSDS

Chlorobutine Synthesis Reference

No information avaliable

Chlorobutine Molecular Weight

304.212 g/mol

Chlorobutine Melting Point

65 oC

Chlorobutine H2O Solubility

1.24E+004 mg/L

Chlorobutine State

Solid

Chlorobutine LogP

3.25

Chlorobutine Dosage Forms

Tablet

Chlorobutine Indication

For treatment of chronic lymphatic (lymphocytic) leukemia, malignant lymphomas including lymphosarcoma, giant follicular lymphoma, and Hodgkin's disease

Chlorobutine Pharmacology

Chlorambucil is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.

Chlorobutine Absorption

No information avaliable

Chlorobutine side effects and Toxicity

No information avaliable

Chlorobutine Patient Information

No information avaliable

Chlorobutine Organisms Affected

Humans and other mammals