Chlorobutine
Chlorobutine Brand names, Chlorobutine Analogs
Chlorobutine Brand Names Mixture
- No information avaliable
Chlorobutine Chemical_Formula
C14H19Cl2NO2
Chlorobutine RX_link
http://www.rxlist.com/cgi/generic2/leukeran.htm
Chlorobutine fda sheet
Chlorobutine msds (material safety sheet)
Chlorobutine Synthesis Reference
No information avaliable
Chlorobutine Molecular Weight
304.212 g/mol
Chlorobutine Melting Point
65 oC
Chlorobutine H2O Solubility
1.24E+004 mg/L
Chlorobutine State
Solid
Chlorobutine LogP
3.25
Chlorobutine Dosage Forms
Tablet
Chlorobutine Indication
For treatment of chronic lymphatic (lymphocytic) leukemia, malignant lymphomas including lymphosarcoma, giant follicular lymphoma, and Hodgkin's disease
Chlorobutine Pharmacology
Chlorambucil is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.
Chlorobutine Absorption
No information avaliable
Chlorobutine side effects and Toxicity
No information avaliable
Chlorobutine Patient Information
No information avaliable
Chlorobutine Organisms Affected
Humans and other mammals
