Chloroambucil
Chloroambucil Brand names, Chloroambucil Analogs
Chloroambucil Brand Names Mixture
- No information avaliable
Chloroambucil Chemical_Formula
C14H19Cl2NO2
Chloroambucil RX_link
http://www.rxlist.com/cgi/generic2/leukeran.htm
Chloroambucil fda sheet
Chloroambucil msds (material safety sheet)
Chloroambucil Synthesis Reference
No information avaliable
Chloroambucil Molecular Weight
304.212 g/mol
Chloroambucil Melting Point
65 oC
Chloroambucil H2O Solubility
1.24E+004 mg/L
Chloroambucil State
Solid
Chloroambucil LogP
3.25
Chloroambucil Dosage Forms
Tablet
Chloroambucil Indication
For treatment of chronic lymphatic (lymphocytic) leukemia, malignant lymphomas including lymphosarcoma, giant follicular lymphoma, and Hodgkin's disease
Chloroambucil Pharmacology
Chlorambucil is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.
Chloroambucil Absorption
No information avaliable
Chloroambucil side effects and Toxicity
No information avaliable
Chloroambucil Patient Information
No information avaliable
Chloroambucil Organisms Affected
Humans and other mammals
