Leukeran
Leukeran Brand names, Leukeran Analogs
Leukeran Brand Names Mixture
- No information avaliable
Leukeran Chemical_Formula
C14H19Cl2NO2
Leukeran RX_link
http://www.rxlist.com/cgi/generic2/leukeran.htm
Leukeran fda sheet
Leukeran msds (material safety sheet)
Leukeran Synthesis Reference
No information avaliable
Leukeran Molecular Weight
304.212 g/mol
Leukeran Melting Point
65 oC
Leukeran H2O Solubility
1.24E+004 mg/L
Leukeran State
Solid
Leukeran LogP
3.25
Leukeran Dosage Forms
Tablet
Leukeran Indication
For treatment of chronic lymphatic (lymphocytic) leukemia, malignant lymphomas including lymphosarcoma, giant follicular lymphoma, and Hodgkin's disease
Leukeran Pharmacology
Chlorambucil is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.
Leukeran Absorption
No information avaliable
Leukeran side effects and Toxicity
No information avaliable
Leukeran Patient Information
No information avaliable
Leukeran Organisms Affected
Humans and other mammals
