Leukeran Tablets
Leukeran Tablets Brand names, Leukeran Tablets Analogs
Leukeran Tablets Brand Names Mixture
- No information avaliable
Leukeran Tablets Chemical_Formula
C14H19Cl2NO2
Leukeran Tablets RX_link
http://www.rxlist.com/cgi/generic2/leukeran.htm
Leukeran Tablets fda sheet
Leukeran Tablets msds (material safety sheet)
Leukeran Tablets Synthesis Reference
No information avaliable
Leukeran Tablets Molecular Weight
304.212 g/mol
Leukeran Tablets Melting Point
65 oC
Leukeran Tablets H2O Solubility
1.24E+004 mg/L
Leukeran Tablets State
Solid
Leukeran Tablets LogP
3.25
Leukeran Tablets Dosage Forms
Tablet
Leukeran Tablets Indication
For treatment of chronic lymphatic (lymphocytic) leukemia, malignant lymphomas including lymphosarcoma, giant follicular lymphoma, and Hodgkin's disease
Leukeran Tablets Pharmacology
Chlorambucil is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.
Leukeran Tablets Absorption
No information avaliable
Leukeran Tablets side effects and Toxicity
No information avaliable
Leukeran Tablets Patient Information
No information avaliable
Leukeran Tablets Organisms Affected
Humans and other mammals
