Fluohydrocortisone
Brand names,
Fluohydrocortisone
Analogs
Fluohydrocortisone
Brand Names Mixture
Fluohydrocortisone
Chemical_Formula
C21H29FO5
Fluohydrocortisone
RX_link
http://www.rxlist.com/cgi/generic/fludro.htm
Fluohydrocortisone
fda sheet
Fluohydrocortisone
msds (material safety sheet)
Fluohydrocortisone
Synthesis Reference
No information avaliable
Fluohydrocortisone
Molecular Weight
380.45 g/mol
Fluohydrocortisone
Melting Point
No information avaliable
Fluohydrocortisone
H2O Solubility
140 mg/L
Fluohydrocortisone
State
Solid
Fluohydrocortisone
LogP
1.49
Fluohydrocortisone
Dosage Forms
Tablet
Fluohydrocortisone
Indication
For partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenogenital syndrome.
Fluohydrocortisone
Pharmacology
Fludrocortisone is a synthetic adrenocortical steroid possessing very potent mineralocorticoid properties and high glucocorticoid activity. It is indicated as partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison’s disease and for the treatment of salt-losing adrenogenital syndrome. The physiologic action of fludrocortisone acetate is similar to that of hydrocortisone. However, the effects of fludrocortisone acetate, particularly on electrolyte balance, but also on carbohydrate metabolism, are considerably heightened and prolonged. Mineralocorticoids act on the distal tubules of the kidney to enhance the reabsorption of sodium ions from the tubular fluid into the plasma; they increase the urinary excretion of both potassium and hydrogen ions.
Fluohydrocortisone
Absorption
No information avaliable
Fluohydrocortisone
side effects and Toxicity
Effects of overexposure include irritation, cardiac edema, increased blood volume, hypertension, cardiac arrhythmias, enlargement of the heart, headaches, and weakness of the extremities.
Fluohydrocortisone
Patient Information
Fluohydrocortisone
Organisms Affected
Humans and other mammals