Fluohydrisone
Brand names,
Fluohydrisone
Analogs
Fluohydrisone
Brand Names Mixture
Fluohydrisone
Chemical_Formula
C21H29FO5
Fluohydrisone
RX_link
http://www.rxlist.com/cgi/generic/fludro.htm
Fluohydrisone
fda sheet
Fluohydrisone
msds (material safety sheet)
Fluohydrisone
Synthesis Reference
No information avaliable
Fluohydrisone
Molecular Weight
380.45 g/mol
Fluohydrisone
Melting Point
No information avaliable
Fluohydrisone
H2O Solubility
140 mg/L
Fluohydrisone
State
Solid
Fluohydrisone
LogP
1.49
Fluohydrisone
Dosage Forms
Tablet
Fluohydrisone
Indication
For partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenogenital syndrome.
Fluohydrisone
Pharmacology
Fludrocortisone is a synthetic adrenocortical steroid possessing very potent mineralocorticoid properties and high glucocorticoid activity. It is indicated as partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison’s disease and for the treatment of salt-losing adrenogenital syndrome. The physiologic action of fludrocortisone acetate is similar to that of hydrocortisone. However, the effects of fludrocortisone acetate, particularly on electrolyte balance, but also on carbohydrate metabolism, are considerably heightened and prolonged. Mineralocorticoids act on the distal tubules of the kidney to enhance the reabsorption of sodium ions from the tubular fluid into the plasma; they increase the urinary excretion of both potassium and hydrogen ions.
Fluohydrisone
Absorption
No information avaliable
Fluohydrisone
side effects and Toxicity
Effects of overexposure include irritation, cardiac edema, increased blood volume, hypertension, cardiac arrhythmias, enlargement of the heart, headaches, and weakness of the extremities.
Fluohydrisone
Patient Information
Fluohydrisone
Organisms Affected
Humans and other mammals