9 .Alpha. Ff
Brand names,
9 .Alpha. Ff
Analogs
9 .Alpha. Ff
Brand Names Mixture
9 .Alpha. Ff
Chemical_Formula
C21H29FO5
9 .Alpha. Ff
RX_link
http://www.rxlist.com/cgi/generic/fludro.htm
9 .Alpha. Ff
fda sheet
9 .Alpha. Ff
msds (material safety sheet)
9 .Alpha. Ff
Synthesis Reference
No information avaliable
9 .Alpha. Ff
Molecular Weight
380.45 g/mol
9 .Alpha. Ff
Melting Point
No information avaliable
9 .Alpha. Ff
H2O Solubility
140 mg/L
9 .Alpha. Ff
State
Solid
9 .Alpha. Ff
LogP
1.49
9 .Alpha. Ff
Dosage Forms
Tablet
9 .Alpha. Ff
Indication
For partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenogenital syndrome.
9 .Alpha. Ff
Pharmacology
Fludrocortisone is a synthetic adrenocortical steroid possessing very potent mineralocorticoid properties and high glucocorticoid activity. It is indicated as partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison’s disease and for the treatment of salt-losing adrenogenital syndrome. The physiologic action of fludrocortisone acetate is similar to that of hydrocortisone. However, the effects of fludrocortisone acetate, particularly on electrolyte balance, but also on carbohydrate metabolism, are considerably heightened and prolonged. Mineralocorticoids act on the distal tubules of the kidney to enhance the reabsorption of sodium ions from the tubular fluid into the plasma; they increase the urinary excretion of both potassium and hydrogen ions.
9 .Alpha. Ff
Absorption
No information avaliable
9 .Alpha. Ff
side effects and Toxicity
Effects of overexposure include irritation, cardiac edema, increased blood volume, hypertension, cardiac arrhythmias, enlargement of the heart, headaches, and weakness of the extremities.
9 .Alpha. Ff
Patient Information
9 .Alpha. Ff
Organisms Affected
Humans and other mammals