PharmacyCodes



F-COL en es it fr

F-COL Brand names, F-COL Analogs

F-COL Brand Names Mixture

  • No information avaliable

F-COL Chemical_Formula

C21H29FO5

F-COL RX_link

http://www.rxlist.com/cgi/generic/fludro.htm

F-COL fda sheet

F-COL msds (material safety sheet)

F-COL MSDS

F-COL Synthesis Reference

No information avaliable

F-COL Molecular Weight

380.45 g/mol

F-COL Melting Point

No information avaliable

F-COL H2O Solubility

140 mg/L

F-COL State

Solid

F-COL LogP

1.49

F-COL Dosage Forms

Tablet

F-COL Indication

For partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenogenital syndrome.

F-COL Pharmacology

Fludrocortisone is a synthetic adrenocortical steroid possessing very potent mineralocorticoid properties and high glucocorticoid activity. It is indicated as partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison’s disease and for the treatment of salt-losing adrenogenital syndrome. The physiologic action of fludrocortisone acetate is similar to that of hydrocortisone. However, the effects of fludrocortisone acetate, particularly on electrolyte balance, but also on carbohydrate metabolism, are considerably heightened and prolonged. Mineralocorticoids act on the distal tubules of the kidney to enhance the reabsorption of sodium ions from the tubular fluid into the plasma; they increase the urinary excretion of both potassium and hydrogen ions.

F-COL Absorption

No information avaliable

F-COL side effects and Toxicity

Effects of overexposure include irritation, cardiac edema, increased blood volume, hypertension, cardiac arrhythmias, enlargement of the heart, headaches, and weakness of the extremities.

F-COL Patient Information

F-COL Organisms Affected

Humans and other mammals