9.Alpha.-Fluorohydrocortisone
Brand names,
9.Alpha.-Fluorohydrocortisone
Analogs
9.Alpha.-Fluorohydrocortisone
Brand Names Mixture
9.Alpha.-Fluorohydrocortisone
Chemical_Formula
C21H29FO5
9.Alpha.-Fluorohydrocortisone
RX_link
http://www.rxlist.com/cgi/generic/fludro.htm
9.Alpha.-Fluorohydrocortisone
fda sheet
9.Alpha.-Fluorohydrocortisone
msds (material safety sheet)
9.Alpha.-Fluorohydrocortisone
Synthesis Reference
No information avaliable
9.Alpha.-Fluorohydrocortisone
Molecular Weight
380.45 g/mol
9.Alpha.-Fluorohydrocortisone
Melting Point
No information avaliable
9.Alpha.-Fluorohydrocortisone
H2O Solubility
140 mg/L
9.Alpha.-Fluorohydrocortisone
State
Solid
9.Alpha.-Fluorohydrocortisone
LogP
1.49
9.Alpha.-Fluorohydrocortisone
Dosage Forms
Tablet
9.Alpha.-Fluorohydrocortisone
Indication
For partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenogenital syndrome.
9.Alpha.-Fluorohydrocortisone
Pharmacology
Fludrocortisone is a synthetic adrenocortical steroid possessing very potent mineralocorticoid properties and high glucocorticoid activity. It is indicated as partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison’s disease and for the treatment of salt-losing adrenogenital syndrome. The physiologic action of fludrocortisone acetate is similar to that of hydrocortisone. However, the effects of fludrocortisone acetate, particularly on electrolyte balance, but also on carbohydrate metabolism, are considerably heightened and prolonged. Mineralocorticoids act on the distal tubules of the kidney to enhance the reabsorption of sodium ions from the tubular fluid into the plasma; they increase the urinary excretion of both potassium and hydrogen ions.
9.Alpha.-Fluorohydrocortisone
Absorption
No information avaliable
9.Alpha.-Fluorohydrocortisone
side effects and Toxicity
Effects of overexposure include irritation, cardiac edema, increased blood volume, hypertension, cardiac arrhythmias, enlargement of the heart, headaches, and weakness of the extremities.
9.Alpha.-Fluorohydrocortisone
Patient Information
9.Alpha.-Fluorohydrocortisone
Organisms Affected
Humans and other mammals