Astonin-H
Brand names,
Astonin-H
Analogs
Astonin-H
Brand Names Mixture
Astonin-H
Chemical_Formula
C21H29FO5
Astonin-H
RX_link
http://www.rxlist.com/cgi/generic/fludro.htm
Astonin-H
fda sheet
Astonin-H
msds (material safety sheet)
Astonin-H
Synthesis Reference
No information avaliable
Astonin-H
Molecular Weight
380.45 g/mol
Astonin-H
Melting Point
No information avaliable
Astonin-H
H2O Solubility
140 mg/L
Astonin-H
State
Solid
Astonin-H
LogP
1.49
Astonin-H
Dosage Forms
Tablet
Astonin-H
Indication
For partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenogenital syndrome.
Astonin-H
Pharmacology
Fludrocortisone is a synthetic adrenocortical steroid possessing very potent mineralocorticoid properties and high glucocorticoid activity. It is indicated as partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison’s disease and for the treatment of salt-losing adrenogenital syndrome. The physiologic action of fludrocortisone acetate is similar to that of hydrocortisone. However, the effects of fludrocortisone acetate, particularly on electrolyte balance, but also on carbohydrate metabolism, are considerably heightened and prolonged. Mineralocorticoids act on the distal tubules of the kidney to enhance the reabsorption of sodium ions from the tubular fluid into the plasma; they increase the urinary excretion of both potassium and hydrogen ions.
Astonin-H
Absorption
No information avaliable
Astonin-H
side effects and Toxicity
Effects of overexposure include irritation, cardiac edema, increased blood volume, hypertension, cardiac arrhythmias, enlargement of the heart, headaches, and weakness of the extremities.
Astonin-H
Patient Information
Astonin-H
Organisms Affected
Humans and other mammals