9 alpha-Fludrocortisone
Brand names,
9 alpha-Fludrocortisone
Analogs
9 alpha-Fludrocortisone
Brand Names Mixture
9 alpha-Fludrocortisone
Chemical_Formula
C21H29FO5
9 alpha-Fludrocortisone
RX_link
http://www.rxlist.com/cgi/generic/fludro.htm
9 alpha-Fludrocortisone
fda sheet
9 alpha-Fludrocortisone
msds (material safety sheet)
9 alpha-Fludrocortisone
Synthesis Reference
No information avaliable
9 alpha-Fludrocortisone
Molecular Weight
380.45 g/mol
9 alpha-Fludrocortisone
Melting Point
No information avaliable
9 alpha-Fludrocortisone
H2O Solubility
140 mg/L
9 alpha-Fludrocortisone
State
Solid
9 alpha-Fludrocortisone
LogP
1.49
9 alpha-Fludrocortisone
Dosage Forms
Tablet
9 alpha-Fludrocortisone
Indication
For partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenogenital syndrome.
9 alpha-Fludrocortisone
Pharmacology
Fludrocortisone is a synthetic adrenocortical steroid possessing very potent mineralocorticoid properties and high glucocorticoid activity. It is indicated as partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison’s disease and for the treatment of salt-losing adrenogenital syndrome. The physiologic action of fludrocortisone acetate is similar to that of hydrocortisone. However, the effects of fludrocortisone acetate, particularly on electrolyte balance, but also on carbohydrate metabolism, are considerably heightened and prolonged. Mineralocorticoids act on the distal tubules of the kidney to enhance the reabsorption of sodium ions from the tubular fluid into the plasma; they increase the urinary excretion of both potassium and hydrogen ions.
9 alpha-Fludrocortisone
Absorption
No information avaliable
9 alpha-Fludrocortisone
side effects and Toxicity
Effects of overexposure include irritation, cardiac edema, increased blood volume, hypertension, cardiac arrhythmias, enlargement of the heart, headaches, and weakness of the extremities.
9 alpha-Fludrocortisone
Patient Information
9 alpha-Fludrocortisone
Organisms Affected
Humans and other mammals