9 Alpha Ff
Brand names,
9 Alpha Ff
Analogs
9 Alpha Ff
Brand Names Mixture
9 Alpha Ff
Chemical_Formula
C21H29FO5
9 Alpha Ff
RX_link
http://www.rxlist.com/cgi/generic/fludro.htm
9 Alpha Ff
fda sheet
9 Alpha Ff
msds (material safety sheet)
9 Alpha Ff
Synthesis Reference
No information avaliable
9 Alpha Ff
Molecular Weight
380.45 g/mol
9 Alpha Ff
Melting Point
No information avaliable
9 Alpha Ff
H2O Solubility
140 mg/L
9 Alpha Ff
State
Solid
9 Alpha Ff
LogP
1.49
9 Alpha Ff
Dosage Forms
Tablet
9 Alpha Ff
Indication
For partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenogenital syndrome.
9 Alpha Ff
Pharmacology
Fludrocortisone is a synthetic adrenocortical steroid possessing very potent mineralocorticoid properties and high glucocorticoid activity. It is indicated as partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison’s disease and for the treatment of salt-losing adrenogenital syndrome. The physiologic action of fludrocortisone acetate is similar to that of hydrocortisone. However, the effects of fludrocortisone acetate, particularly on electrolyte balance, but also on carbohydrate metabolism, are considerably heightened and prolonged. Mineralocorticoids act on the distal tubules of the kidney to enhance the reabsorption of sodium ions from the tubular fluid into the plasma; they increase the urinary excretion of both potassium and hydrogen ions.
9 Alpha Ff
Absorption
No information avaliable
9 Alpha Ff
side effects and Toxicity
Effects of overexposure include irritation, cardiac edema, increased blood volume, hypertension, cardiac arrhythmias, enlargement of the heart, headaches, and weakness of the extremities.
9 Alpha Ff
Patient Information
9 Alpha Ff
Organisms Affected
Humans and other mammals