9.Alpha.-Fluorocortisol
Brand names,
9.Alpha.-Fluorocortisol
Analogs
9.Alpha.-Fluorocortisol
Brand Names Mixture
9.Alpha.-Fluorocortisol
Chemical_Formula
C21H29FO5
9.Alpha.-Fluorocortisol
RX_link
http://www.rxlist.com/cgi/generic/fludro.htm
9.Alpha.-Fluorocortisol
fda sheet
9.Alpha.-Fluorocortisol
msds (material safety sheet)
9.Alpha.-Fluorocortisol
Synthesis Reference
No information avaliable
9.Alpha.-Fluorocortisol
Molecular Weight
380.45 g/mol
9.Alpha.-Fluorocortisol
Melting Point
No information avaliable
9.Alpha.-Fluorocortisol
H2O Solubility
140 mg/L
9.Alpha.-Fluorocortisol
State
Solid
9.Alpha.-Fluorocortisol
LogP
1.49
9.Alpha.-Fluorocortisol
Dosage Forms
Tablet
9.Alpha.-Fluorocortisol
Indication
For partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenogenital syndrome.
9.Alpha.-Fluorocortisol
Pharmacology
Fludrocortisone is a synthetic adrenocortical steroid possessing very potent mineralocorticoid properties and high glucocorticoid activity. It is indicated as partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison’s disease and for the treatment of salt-losing adrenogenital syndrome. The physiologic action of fludrocortisone acetate is similar to that of hydrocortisone. However, the effects of fludrocortisone acetate, particularly on electrolyte balance, but also on carbohydrate metabolism, are considerably heightened and prolonged. Mineralocorticoids act on the distal tubules of the kidney to enhance the reabsorption of sodium ions from the tubular fluid into the plasma; they increase the urinary excretion of both potassium and hydrogen ions.
9.Alpha.-Fluorocortisol
Absorption
No information avaliable
9.Alpha.-Fluorocortisol
side effects and Toxicity
Effects of overexposure include irritation, cardiac edema, increased blood volume, hypertension, cardiac arrhythmias, enlargement of the heart, headaches, and weakness of the extremities.
9.Alpha.-Fluorocortisol
Patient Information
9.Alpha.-Fluorocortisol
Organisms Affected
Humans and other mammals