Phythyl-menadion_(GERMAN)
Category
Phythyl-menadion_(GERMAN) Brand names, Phythyl-menadion_(GERMAN) Analogs
Phythyl-menadion_(GERMAN) Brand Names Mixture
No information avaliable
Phythyl-menadion_(GERMAN) Chemical_Formula
C31H46O2
Phythyl-menadion_(GERMAN) RX_link
http://www.rxlist.com/cgi/generic3/phytonadione.htm
Phythyl-menadion_(GERMAN) fda sheet
Phythyl-menadion_(GERMAN) msds (material safety sheet)
Phythyl-menadion_(GERMAN) Synthesis Reference
No information avaliable
Phythyl-menadion_(GERMAN) Molecular Weight
450.696 g/mol
Phythyl-menadion_(GERMAN) Melting Point
-20 oC
Phythyl-menadion_(GERMAN) H2O Solubility
Insoluble in water
Phythyl-menadion_(GERMAN) State
Liquid
Phythyl-menadion_(GERMAN) LogP
8.841
Phythyl-menadion_(GERMAN) Dosage Forms
Liquid
Phythyl-menadion_(GERMAN) Indication
For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia
Phythyl-menadion_(GERMAN) Pharmacology
Phytonadione is a vitamin, indicated in the treatment of coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. Phytonadione aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X).
Phythyl-menadion_(GERMAN) Absorption
Oral phytonadione is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phytonadione is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues.
Phythyl-menadion_(GERMAN) Toxicity
No information avaliable
Phythyl-menadion_(GERMAN) Patient Information
No information avaliable
Phythyl-menadion_(GERMAN) Organisms Affected
Humans and other mammals
