Phytomenadione
Category
Phytomenadione Brand names, Phytomenadione Analogs
Phytomenadione Brand Names Mixture
No information avaliable
Phytomenadione Chemical_Formula
C31H46O2
Phytomenadione RX_link
http://www.rxlist.com/cgi/generic3/phytonadione.htm
Phytomenadione fda sheet
Phytomenadione msds (material safety sheet)
Phytomenadione Synthesis Reference
No information avaliable
Phytomenadione Molecular Weight
450.696 g/mol
Phytomenadione Melting Point
-20 oC
Phytomenadione H2O Solubility
Insoluble in water
Phytomenadione State
Liquid
Phytomenadione LogP
8.841
Phytomenadione Dosage Forms
Liquid
Phytomenadione Indication
For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia
Phytomenadione Pharmacology
Phytonadione is a vitamin, indicated in the treatment of coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. Phytonadione aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X).
Phytomenadione Absorption
Oral phytonadione is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phytonadione is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues.
Phytomenadione Toxicity
No information avaliable
Phytomenadione Patient Information
No information avaliable
Phytomenadione Organisms Affected
Humans and other mammals
