Kativ_N
Category
Kativ_N Brand names, Kativ_N Analogs
Kativ_N Brand Names Mixture
No information avaliable
Kativ_N Chemical_Formula
C31H46O2
Kativ_N RX_link
http://www.rxlist.com/cgi/generic3/phytonadione.htm
Kativ_N fda sheet
Kativ_N msds (material safety sheet)
Kativ_N Synthesis Reference
No information avaliable
Kativ_N Molecular Weight
450.696 g/mol
Kativ_N Melting Point
-20 oC
Kativ_N H2O Solubility
Insoluble in water
Kativ_N State
Liquid
Kativ_N LogP
8.841
Kativ_N Dosage Forms
Liquid
Kativ_N Indication
For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia
Kativ_N Pharmacology
Phytonadione is a vitamin, indicated in the treatment of coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. Phytonadione aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X).
Kativ_N Absorption
Oral phytonadione is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phytonadione is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues.
Kativ_N Toxicity
No information avaliable
Kativ_N Patient Information
No information avaliable
Kativ_N Organisms Affected
Humans and other mammals
