Monodion
Category
Monodion Brand names, Monodion Analogs
Monodion Brand Names Mixture
No information avaliable
Monodion Chemical_Formula
C31H46O2
Monodion RX_link
http://www.rxlist.com/cgi/generic3/phytonadione.htm
Monodion fda sheet
Monodion msds (material safety sheet)
Monodion Synthesis Reference
No information avaliable
Monodion Molecular Weight
450.696 g/mol
Monodion Melting Point
-20 oC
Monodion H2O Solubility
Insoluble in water
Monodion State
Liquid
Monodion LogP
8.841
Monodion Dosage Forms
Liquid
Monodion Indication
For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia
Monodion Pharmacology
Phytonadione is a vitamin, indicated in the treatment of coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. Phytonadione aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X).
Monodion Absorption
Oral phytonadione is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phytonadione is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues.
Monodion Toxicity
No information avaliable
Monodion Patient Information
No information avaliable
Monodion Organisms Affected
Humans and other mammals
