Kephton
Category
Kephton Brand names, Kephton Analogs
Kephton Brand Names Mixture
No information avaliable
Kephton Chemical_Formula
C31H46O2
Kephton RX_link
http://www.rxlist.com/cgi/generic3/phytonadione.htm
Kephton fda sheet
Kephton msds (material safety sheet)
Kephton Synthesis Reference
No information avaliable
Kephton Molecular Weight
450.696 g/mol
Kephton Melting Point
-20 oC
Kephton H2O Solubility
Insoluble in water
Kephton State
Liquid
Kephton LogP
8.841
Kephton Dosage Forms
Liquid
Kephton Indication
For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia
Kephton Pharmacology
Phytonadione is a vitamin, indicated in the treatment of coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. Phytonadione aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X).
Kephton Absorption
Oral phytonadione is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phytonadione is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues.
Kephton Toxicity
No information avaliable
Kephton Patient Information
No information avaliable
Kephton Organisms Affected
Humans and other mammals
