Phylloquinone
Category
Phylloquinone Brand names, Phylloquinone Analogs
Phylloquinone Brand Names Mixture
No information avaliable
Phylloquinone Chemical_Formula
C31H46O2
Phylloquinone RX_link
http://www.rxlist.com/cgi/generic3/phytonadione.htm
Phylloquinone fda sheet
Phylloquinone msds (material safety sheet)
Phylloquinone Synthesis Reference
No information avaliable
Phylloquinone Molecular Weight
450.696 g/mol
Phylloquinone Melting Point
-20 oC
Phylloquinone H2O Solubility
Insoluble in water
Phylloquinone State
Liquid
Phylloquinone LogP
8.841
Phylloquinone Dosage Forms
Liquid
Phylloquinone Indication
For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia
Phylloquinone Pharmacology
Phytonadione is a vitamin, indicated in the treatment of coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. Phytonadione aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X).
Phylloquinone Absorption
Oral phytonadione is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phytonadione is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues.
Phylloquinone Toxicity
No information avaliable
Phylloquinone Patient Information
No information avaliable
Phylloquinone Organisms Affected
Humans and other mammals
