Phyllochinon
Category
Phyllochinon Brand names, Phyllochinon Analogs
Phyllochinon Brand Names Mixture
No information avaliable
Phyllochinon Chemical_Formula
C31H46O2
Phyllochinon RX_link
http://www.rxlist.com/cgi/generic3/phytonadione.htm
Phyllochinon fda sheet
Phyllochinon msds (material safety sheet)
Phyllochinon Synthesis Reference
No information avaliable
Phyllochinon Molecular Weight
450.696 g/mol
Phyllochinon Melting Point
-20 oC
Phyllochinon H2O Solubility
Insoluble in water
Phyllochinon State
Liquid
Phyllochinon LogP
8.841
Phyllochinon Dosage Forms
Liquid
Phyllochinon Indication
For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia
Phyllochinon Pharmacology
Phytonadione is a vitamin, indicated in the treatment of coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. Phytonadione aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X).
Phyllochinon Absorption
Oral phytonadione is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phytonadione is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues.
Phyllochinon Toxicity
No information avaliable
Phyllochinon Patient Information
No information avaliable
Phyllochinon Organisms Affected
Humans and other mammals
