Konakion
Category
Konakion Brand names, Konakion Analogs
Konakion Brand Names Mixture
No information avaliable
Konakion Chemical_Formula
C31H46O2
Konakion RX_link
http://www.rxlist.com/cgi/generic3/phytonadione.htm
Konakion fda sheet
Konakion msds (material safety sheet)
Konakion Synthesis Reference
No information avaliable
Konakion Molecular Weight
450.696 g/mol
Konakion Melting Point
-20 oC
Konakion H2O Solubility
Insoluble in water
Konakion State
Liquid
Konakion LogP
8.841
Konakion Dosage Forms
Liquid
Konakion Indication
For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia
Konakion Pharmacology
Phytonadione is a vitamin, indicated in the treatment of coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. Phytonadione aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X).
Konakion Absorption
Oral phytonadione is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phytonadione is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues.
Konakion Toxicity
No information avaliable
Konakion Patient Information
No information avaliable
Konakion Organisms Affected
Humans and other mammals
