Kinadion
Category
Kinadion Brand names, Kinadion Analogs
Kinadion Brand Names Mixture
No information avaliable
Kinadion Chemical_Formula
C31H46O2
Kinadion RX_link
http://www.rxlist.com/cgi/generic3/phytonadione.htm
Kinadion fda sheet
Kinadion msds (material safety sheet)
Kinadion Synthesis Reference
No information avaliable
Kinadion Molecular Weight
450.696 g/mol
Kinadion Melting Point
-20 oC
Kinadion H2O Solubility
Insoluble in water
Kinadion State
Liquid
Kinadion LogP
8.841
Kinadion Dosage Forms
Liquid
Kinadion Indication
For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia
Kinadion Pharmacology
Phytonadione is a vitamin, indicated in the treatment of coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. Phytonadione aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X).
Kinadion Absorption
Oral phytonadione is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phytonadione is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues.
Kinadion Toxicity
No information avaliable
Kinadion Patient Information
No information avaliable
Kinadion Organisms Affected
Humans and other mammals
